外泌体长链非编码RNA在胃癌中的研究进展 [中文引用][英文引用]

 【摘要】外泌体为一种稳定且广泛存在于人类体液中的纳米级囊泡，特殊的结构使其能够介导一种新的细胞间通讯模式，并参与肿瘤的发生发展，是近年来的研究热点。近期研究表明，外泌体LncRNAs不仅可以作为胃癌诊断的新型生物标志物，甚至参与胃癌细胞的增殖、凋亡和肿瘤微环境的改变以及化疗耐受。因此，本文对近年来外泌体LncRNAs在胃癌中的上述研究进展进行综述，期望为进一步研究提供参考和新的思路。

 【Abstract】  Exosomes are stable nanoscale vesicles that widely exist in human body fluids. Exosomes have become a research hot topic in recent years because of their special structure, which enables them to mediate a new mode of intercellular communication and participate in the occurrence and development of tumors. Recent studies have shown that exosomal LncRNAs can not only be used as novel biomarkers for the diagnosis of gastric cancer, but also participate in the proliferation and apoptosis of gastric cancer cells, changes in tumor microenvironment and chemotherapy tolerance. Therefore, this review on the above aspects of exosomal LncRNAs in gastric cancer in recent years is expected to provide references and new ideas for further research.