针刀调节交感神经对老年胃溃疡患者胃功能和溃疡愈合的影响 [中文引用][英文引用]

【摘要】目的 探讨针刀调节交感神经应用于老年胃溃疡患者对胃功能和溃疡愈合的影响。方法 采用单中心、前瞻性、随机对照队列研究方法，选择2021年1月至2022年12月在山东中医药大学附属医院推拿科诊治的112例老年胃溃疡患者作为研究对象，按照随机数字表法1：1分为对照组（56例）和研究组（56例）。对照组接受常规西医治疗，研究组在对照组基础上给予针刀调节交感神经治疗，对比两组在治疗前后幽门螺杆菌转阴情况 、胃功能情况、溃疡愈合、血清炎症因子以及不良反应等。结果 研究组治疗总有效率（94.64%）明显优于对照组（80.36%），差异有统计学意义（P＜0.05）。研究组幽门螺杆菌转阴率（87.50%）明显优于对照组（71.43%），差异有统计学意义（P＜0.05）。治疗后，研究组胃排空时间及胃窦部收缩频率，缩胆囊素、胃泌素、胃动素指标，溃疡愈合指标，炎症指标TNF-α、三叶因子2（TFF2）、IL-4以及IL-8均明显优于对照组（P＜0.05）。研究组不良反应发生率为16.07%略高于对照组的12.50%，但差异无统计学意义（P＞0.05）。结论 针刀调节交感神经应用于老年胃溃疡患者，能够提高治疗效果，改善胃功能和溃疡愈合，促进血清炎症因子指标恢复。

 [Abstract]  Objective  To explore the effect of acupotomy regulation of sympathetic nervous on gastric function and ulcer healing in elderly gastric ulcer patients. Methods  A single center, prospective, randomized controlled cohort study was used. A total of 112 elderly patients with gastric ulcer in Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2021 to December 2022 were selected as the study subjects. They were divided into control group (56 cases) and research group (56 cases) according to the random number table method. The control group received conventional Western medicine treatment. On the basis of the control group, the research group received acupotomy regulation of sympathetic nerve therapy. The Helicobacter pylori (Hp) negative conversion, gastric function, ulcer healing, serum inflammatory factors, and adverse reactions between the two groups were compared. Results  The research group was significantly better than the control group in terms of treatment effectiveness, with statistically significant difference (94.64% vs. 80.36%, P<0.05). The negative conversion rate of Hp in the research group (87.50%) was significantly higher than that in the control group (71.43%), with statistically significant difference (P<0.05). After treatment, the gastric emptying time, gastric antral contraction frequency, cholecystokinin, gastrin, motilin, ulcer healing indicators, inflammatory indicators TNF-α, trefoil factor 2 (TFF2), IL-4 and IL-8 in the research group were significantly better than those in the control group (P<0.05). The incidence of adverse reactions in the research group was 16.07%, slightly higher than the control group’s 12.50%, but there was no statistically significant difference (P>0.05). Conclusion  The application of acupotomy regulation of sympathetic nerves in elderly gastric ulcer patients can improve treatment effectiveness, improve gastric function and ulcer healing, and promote the recovery of serum inflammatory factor indicators.