食管癌患者肿瘤组织CXCL5和CXCR2的表达与病情和预后的相关性分析 [中文引用][英文引用]

【摘要】目的：研究食管癌患者肿瘤组织CXC趋化因子5（CXCL5）和CXC趋化因子受体2（CXCR2）水平对食管癌病情及预后的影响，为食管癌临床诊断、治疗和评价预后提供新方向。方法：选取2013年8月至2015年7月于徐州医科大学附属医院确诊且临床资料完整的126例未经放化疗的食管癌患者作为研究对象，通过免疫组织化学染色的方法检测食管癌组织CXCL5和CXCR2表达水平，探讨CXCL5和CXCR2表达水平与食管癌临床病理分型和生存预后的关系。结果：食管癌组织CXCL5和CXCR2的表达阳性率显著高于癌旁组织（P<0.05），且两者存在相关性（P<0.05）；食管癌组织CXCL5和CXCR2与食管癌TNM分期和淋巴结转移具有显著的相关性（P<0.05）；生存曲线显示，食管癌组织CXCL5、CXCR2阳性的患者5年生存率和预期生存时间显著低于阴性者，差异有统计学意义（P<0.05）；Cox多因素分析显示原发肿瘤部位、食管癌TNM分期、淋巴结转移和食管癌组织CXCL5、CXCR2水平为食管癌预后的独立危险因素（P<0.05）。结论：食管癌患者肿瘤组织内CXCL5、CXCR2高表达，与食管癌病情相关，CXCL5、CXCR2是影响食管癌患者预后的独立危险因素。

 【Abstract】  Objective  To investigate the effects of C-X-C motif chemokine ligand 5 (CXCL5) and C-X-C motif chemokine receptor 2 (CXCR2) levels in tumor tissue of esophageal cancer patients on the condition and prognosis of esophageal cancer, and to provide a new direction for clinical diagnosis, treatment and prognosis evaluation of esophageal cancer. Methods  A total of 126 patients with esophageal cancer without radiotherapy and chemotherapy who were diagnosed at the Affiliated Hospital of Xuzhou Medical University from August 2013 to July 2015 and had complete clinical data were selected as the research objects. The expression levels of CXCL5 and CXCR2 in esophageal cancer tissues were detected by immunohistochemical staining, and the relationships between the expression levels of CXCL5 and CXCR2 and the clinicopathological classification and survival prognosis of esophageal cancer were explored. Results  The positive expression rates of CXCL5 and CXCR2 in esophageal cancer tissues were significantly higher than those in adjacent tissues (P<0.05), and there was a correlation between the two (P<0.05). CXCL5 and CXCR2 in esophageal cancer tissues were significantly correlated with TNM stage and lymph node metastasis of esophageal cancer (P<0.05). The survival curve showed that the 5-year survival rate and expected survival time of patients with CXCL5 and CXCR2 positive esophageal cancer tissues were significantly lower than those with negative esophageal cancer tissues, with a statistically significant difference (P<0.05). Cox multivariate analysis showed that the location of primary tumor, TNM stage of esophageal cancer, lymph node metastasis and the levels of CXCL5 and CXCR2 in esophageal cancer tissues were independent risk factors for the prognosis of esophageal cancer (P<0.05). Conclusion  The high expressions of CXCL5 and CXCR2 in tumor tissues of patients with esophageal cancer are related to the condition of esophageal cancer. CXCL5 and CXCR2 are independent risk factors affecting the prognosis of patients with esophageal cancer.