滨海县非酒精性脂肪肝发病与消退的影响因素分析 [中文引用][英文引用]

 【摘要】目的：研究江苏省滨海县非酒精性脂肪肝(NAFLD)的发病和消退情况及其影响因素。方法：选取2017年、2019年两年均在某医院参加健康体检的居民5196名，收集其生化指标和肝脏彩超检查结果等资料。结果：基线无脂肪肝人群NAFLD两年累积发病率15.47%；基线NAFLD患者两年累积消退率29.64%。男性发病率(20.18%)高于女性(12.91%)，差异有统计学意义（P<0.001）；女性消退率(32.27%)高于男性(27.97%),差异有统计学意义（P=0.010）。NAFLD的发病率随着年龄的升高而升高（P<0.001）；消退率不随年龄的变化而变化（P=0.81）。随着体重指数（BMI）的升高，NAFLD的发病率呈增高趋势（P<0.001），消退率呈降低趋势（P<0.001）。基线BMI、总胆固醇、甘油三酯等指标异常是非酒精性脂肪肝发病的危险因素；而血压、BMI等与非酒精性脂肪肝消退也具有显著性关联。结论：BMI是非酒精性脂肪肝发病和消退的重要影响因素，提示控制体重是降低非酒精性脂肪肝发病率，提高消退率的有效措施。

 [Abstract]  Objective  To explore the incidence and remission of non-alcoholic fatty liver disease (NAFLD) in Binhai County, Jiangsu Province, and its influencing factors. Methods  The 5 916 people who underwent health examinations both in 2017 and 2019 were participated in the study, and the biochemical indicators results and liver color Doppler ultrasound results were collected. Results  The two-year cumulative incidence of NAFLD in the baseline population without fatty liver disease was 15.47%, and the two-year cumulative remission rate of baseline NAFLD patients was 29.64%. The incidence in males (20.18%) was higher than that in females (12.91%), with a statistically significant difference (P<0.001). The remission rate of females (32.27%) was higher than that of males (27.97%), with a statistically significant difference (P=0.010). With the increase of age, the incidence of NAFLD increased (P<0.001), but the remission rate didn’t change (P=0.81). The incidence of NAFLD increased (P<0.001) and the remission rate decreased (P<0.001) with increasing body mass index (BMI). Abnormal baseline BMI, total cholesterol, triglyceride and other indicators were risk factors of the NAFLD; while blood pressure and BMI were independent influencing factors for the remission of NAFLD. Conclusion  BMI is an important influencing factor for the incidence and remission of NAFLD, suggesting that weight control is an effective measure to reduce the incidence of NAFLD and increase the regression rate.